What are Epithelial Alarmins and Why are they Important? New Understanding of Severe Asthma Pathophysiology and the Inflammatory Cascade
Speakers: Flavia Cecilia Lega Hoyte, MD, Fellowship Training Program DirectorMichael Wechsler, MD, MMSc, Director of The Cohen Family Asthma Institute
Duration: 60 minutes
Presented on: June 9, 2021
What are Epithelial Alarmins and Why are They Important? – New Understanding of Severe Asthma Pathophysiology and the Inflammatory Cascade
LEARNING OBJECTIVESAt the conclusion of this activity, participants will be able to:
This activity is provided by National Jewish Health.
- Define the epithelial alarmins and their pivotal role in inflammation in asthma
- Describe how the epithelial alarmins impact both T2 and non-T2 downstream inflammation in asthma
- Explain how therapies, such as anti-TSLP, would be expected to modulate airway inflammation in patients with either a T2-high or T2-low phenotype
- Evaluate the results of clinical trials of novel therapies that target the epithelial alarmins
This educational activity is supported by an educational grant from AstraZeneca Pharmaceuticals LP.
- Physicians – 1.0 AMA PRA Category 1 Credit™
Target AudiencePulmonologists, allergists, nurse practitioners, and physician assistants in these specialties.
Duration of ActivityJune 9, 2021 – June 9, 2022
Accreditation StatementNational Jewish Health is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit DesignationNational Jewish Health designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Disclosure of Financial RelationshipsIn accordance with the Accreditation Council for Continuing Medical Education (ACCME), National Jewish Health requires that all program faculty, content developers, reviewers, and others in a position to control the content of this activity disclose to learners the presence or absence of any relevant financial relationships with an ACCME-defined ineligible company. The ACCME defines an “ineligible company” as one whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. Our goal is to ensure that there is no compromise in the ethical relationship that exists between those in a position to control the content of the activity and those participating in the activity and their respective professional duties. All accredited education activities offered by National Jewish Health are reviewed to ensure a balanced and evidence-based presentation.
All relevant financial relationships among individuals in a position to control the content of this activity have been identified and mitigated according to the Standards of Integrity and Independence in Accredited Education.
Faculty DisclosuresMichael E. Wechsler, MD, MMSc declares he is a consultant and investigator for AstraZeneca and a consultant for Amgen.
Flavia Cecilia Lega Hoyte, MD declares she is on an advisory board for AstraZeneca.
Planners and ReviewersMeghan Brenner, MA declares she has no relevant financial relationships.
Anthony Gerber, MD declares he is a consultant for BeiGene, Pliant Therapeutics, and Biosciences Pharma.
Andrea Harshman, MHA, CHCP, CMP-HC declares she has no relevant financial relationships.
Harold S Nelson, MD declares he is a consultant for ALK and on a data safety monitoring board for AstraZeneca.
Lauren Rieck declares she has no relevant financial relationships.
Disclosure of Unlabeled UseThe faculty of this educational activity may include discussions of products or devices that are not currently labeled for use by the FDA. Faculty members have been advised to disclose to the audience any reference to an unlabeled or investigational use.
No endorsement of unapproved products or uses is made or implied by coverage of these products or uses in our reports. No responsibility is taken for errors or omissions in reports.
Please refer to the official prescribing information for each product for discussion of approved indicators, contraindications and warnings.
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